Ịnagide ahụike n'oge ime

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Immune tolerance in pregnancy maobu maternal immune tolerance bu n'abata ahuike nke ana ahu ebe nwa na placenta no n'oge nwaanyi di ime. N'abata na ebute ahuike nke n'aju n'abata ahu ozo dika nke na eme na spontaneous abortion. Ana agu gbasara isiokwua na reproductive immunology.[1][2]

  • Ọrịa Rh na-akpata site na nne na-emepụta antibodies (gụnyere IgG antibodies) megide Rhesus D antigen na mkpụrụ ndụ ọbara ọbara ọbara nwa ha. Ọ na-eme ma ọ bụrụ na nne ahụ enweghị Rh na nwa ahụ nwere Rh, na obere ọbara Rh sitere na ime ime ọ bụla gara aga abanyewo na mgbasa nke nne iji mepụta IgG antibodies megide D antigen (Anti-D). IgG nne nwere ike ịgafe placenta n'ime nwa e bu n'afọ ma ọ bụrụ na ọkwa ya ezuola, ọ ga-akpata mbibi nke mkpụrụ ndụ ọbara uhie nke nwa e bu, na-eduga na mmepe nke ụdị ọrịa hemolytic anti-Rh nke nwa e butere na nwa ọhụrụ (HDFN). N'ozuzu, HDFN na-akawanye njọ na afọ ime Rh ọ bụla na-ekwekọghị.
  • Otu ihe na-akpata pre-eclampsia bụ mmeghachi omume na-adịghị mma nke ahụike na placenta. E nwere ihe akaebe siri ike maka ikpughe ọbara ọcha nke onye òtù ọlụlụ dị ka mgbochi maka pre-eclampsia, n'ụzọ dị ukwuu n'ihi ịmịkọrọ ọtụtụ ihe na-agbanwe usoro ahụike dị na mmiri.[3][4]

Ime ime sitere na Onyinye àkwá, ebe onye na-ebu ya yiri nwa e bu n'afọ karịa nne, na-ejikọta ya na oke ọbara mgbali elu nke ime ime ime na Ọrịa placental.[5] Mgbanwe nke mpaghara na nke usoro ahụike na-apụta ìhè karịa na ime ime nkịtị, n'ihi ya, a tụwo aro na ọnụọgụ dị elu nke ọnọdụ ụfọdụ na onyinye àkwá nwere ike ịbụ site na mbelata nke ikike ahụike site n'aka nne.[1][5]

Enweghị ike ịmụ nwa na ime ọpụpụ[dezie | dezie ebe o si]

Antiphospholipid antibodies na-elekwasị anya na phospholipids nke membrane nke mkpụrụ ndụ. Nnyocha egosila na ndị na-alụso phosphatidylserine, phosphatidylcholine, phosphatidylglycerol, phospaditylinositol na phosphatidylethanolamine ọgụ na-elekwasị anya na pre-embryo. Antibodies megide phosphatidylserine na phosphatidylethanolamine na-emegide trophoblast. Phospholipids ndị a dị mkpa n'ime ka mkpụrụ ndụ nke nwa e bu n'afọ nọgide na-ejikọta na mkpụrụ ndụ nke akpa nwa site na itinye ya. Ọ bụrụ na nwanyị nwere ndị na-alụso phospholipids ndị a ọgụ, a ga-ebibi ha site na mmeghachi omume nke ahụike na n'ikpeazụ nwa e bu n'afọ agaghị enwe ike ịnọgide na-ejikọta ya na akpa nwa. Ndị na-alụso ọrịa ọgụ na-emekwa ka ahụike nke akpa nwa ghara ịdị irè site n'ịgbanwe ọbara na-aga n'akpa nwa.[1][6]

N'agbanyeghị nke ahụ, ọ dịghị ọgwụ ọ bụla ugbu a nke nwere ihe akaebe nke igbochi ime ọpụpụ site na igbochi mmeghachi omume nke mmegide nne; aspirin enweghị mmetụta na nke a.[7]

Mmụba nke ibute ọrịa[dezie | dezie ebe o si]

Ime ime n'etiti ụdị[dezie | dezie ebe o si]

Ọ bụrụ na enwere ike ịghọta usoro nke ịjụ-immunity nke nwa e bu n'afọ, ọ nwere ike iduga n'ime ime n'etiti ụdị, na-enwe, dịka ọmụmaatụ, ezì na-ebu nwa e bu pụta ụwa dị ka onye ọzọ na-anọchi anya nne mmadụ.[8]

  1. ↑ Williams (20 Sep 2012). "Inducing Tolerance to Pregnancy". New England Journal of Medicine 367 (12): 1159–1161. DOI:10.1056/NEJMcibr1207279. PMID 22992082. 
  2. ↑ (March 1986) "Active suppression of host-vs-graft reaction in pregnant mice. VII. Spontaneous abortion of allogeneic CBA/J x DBA/2 fetuses in the uterus of CBA/J mice correlates with deficient non-T suppressor cell activity". J. Immunol. 136 (5): 1668–75. DOI:10.4049/jimmunol.136.5.1668. PMID 2936806. 
  3. ↑ Robertson. Research Goals / Role of seminal fluid signalling in the female reproductive tract. Archived from the original on 2012-03-29.
  4. ↑ Sarah A. Robertson (August 2003). "Seminal 'priming' for protection from pre-eclampsia—a unifying hypothesis". Journal of Reproductive Immunology 59 (2): 253–265. DOI:10.1016/S0165-0378(03)00052-4. PMID 12896827. 
  5. ↑ 5.0 5.1 Van Der Hoorn (Nov–Dec 2010). "Clinical and immunologic aspects of egg donation pregnancies: a systematic review". Human Reproduction Update 16 (6): 704–12. DOI:10.1093/humupd/dmq017. PMID 20543201. 
  6. ↑ Kpọpụta njehie: Invalid <ref> tag; no text was provided for refs named Gronowski
  7. ↑ Kaandorp (29 April 2010). "Aspirin plus Heparin or Aspirin Alone in Women with Recurrent Miscarriage". New England Journal of Medicine 362 (17): 1586–1596. DOI:10.1056/NEJMoa1000641. PMID 20335572. 
  8. ↑ Darwin's children LeVay, Simon. (1997, October 14). from The Free Library. (1997). Retrieved March 06, 2009
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